The Historic US 80 Byway travels from Ruston to the Mississippi state line, offering scenic views of farmland and forests. Ruston is famous for its peaches and also boasts an 18-block historic district with small shops and museums. Further east, Monroe and West Monroe, located along the Ouachita River, feature the Biedenharn Museum and Gardens, the Chennault Aviation and Military Museum, and D’Arbonne National Wildlife Refuge. The latter known for its diverse wildlife and walking trails.

Continuing along the byway, travelers can visit Poverty Point in Epps, a UNESCO World Heritage Site older than the Egyptian pyramids, featuring significant prehistoric earthworks. Archaeologists have excavated hundreds of acres to learn about its ancient inhabitants. Nearby visitors can stop at the Tensas River National Wildlife Refuge, home to various bird species, and the Southern Heritage Air Foundation museum, which preserves aviation history and stories from U.S. service members.

This historic route blends natural beauty, cultural heritage, and significant archaeological sites, making it a unique and enriching journey through northern Louisiana.