The Wyoming Centennial Scenic Byway provides travellers with a rich aesthetic, cultural and historical experience, as well as views of diverse landscapes and ecosystems. It crosses the Continental Divide, and offers a route that, although well-traveled, is "off the beaten path" between Grand Teton and Yellowstone National Parks. The route provides a loop opportunity for visitors to these two famous National Parks, and is part of the Federal Highway system that includes other nearby scenic byways, such as the Beartooth Highway.

Travel the byway from Dubois to Pinedale and see some of the continent's most wild and spectacular country. The byway crosses, and gives public access to, the recreation lands of two National Forests, Grand Teton National Park, the National Elk Refuge in Jackson Hole, and numerous private resorts and services. Although passing through a progression of dramatic scenery, from high alpine confier forests to willow bottoms and sage covered hills, is an attraction worth the journey by itself.